Cambrena is located some twenty kilometres from the renowned holiday resort of St. Moritz, the duty-free resort of Livigno and Valposchiavo.

The hotel may be reached by car in summer and winter via the Bernina Pass along a safe and comfortable route through magnificent scenery.

For those who enjoy travelling by train, Ospizio Bernina may be reached via the Bernina Express, which links Tirano and St. Moritz, reaching an altitude of 2,253 metres, the highest point reached by any train in Europe without a rack railway. The railway line has become a major tourist attraction within the region.